Noninvasive tracking of gene expression by reporter transgene imaging
نویسندگان
چکیده
منابع مشابه
Noninvasive tracking of gene expression by reporter transgene imaging.
I n this issue of PNAS, the laboratory that discovered leptin (1) reports the development of a novel in vivo imaging strategy that permits noninvasive estimation of leptin expression (2). They have engineered a BAC transgenic mouse strain expressing a luciferase reporter gene under the control of adipocyte-specific leptin regulatory sequences. Because of the ample evidence of correlation betwee...
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UNLABELLED Indirect, noninvasive imaging of therapeutic gene expression based on levels of reporter gene expression is a powerful tool to devise improved therapeutic strategies in cancer gene therapy. The use of bicistronic vectors carrying internal ribosome entry sites (IRESs) allows the coexpression of multiple gene products from the same promoter but leads to considerable attenuation of the ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0806875105